New PAD Guidelines; AHA on Postpartum Care; Exercise Didn’t Stop CAC Progression

Low-dose rivaroxaban (Xarelto), SGLT2 inhibitors, and GLP-1 receptor agonists have entered multisocietal guidelines on peripheral artery disease (PAD) for the first time. (Circulation)

Recommendations for postpartum care were released by the American Heart Association, and include monitoring for risk factors during routine pre-conception and interconception care.

An observational cohort study found that preeclampsia was associated with a long-term risk of arrhythmias. (European Journal of Preventive Cardiology)

Ninerafaxstat, a novel cardiac mitotrope, showed promise in a phase II trial of patients with symptomatic nonobstructive hypertrophic cardiomyopathy. (Journal of the American College of Cardiology)

The FDA said that the HeartMate 3 left ventricular assist system implant kit is under class I recall due to issues with blood leakage and air entry, including two related deaths.

The Kansas City Medical Optimization score can be used as a measure of guideline-directed medical therapy intensity in heart failure. (Circulation: Heart Failure)

The manufacturer-agnostic remote monitoring algorithm SignalHF was granted FDA 510(k) clearance, Implicity announced.

A SMART trial substudy found that the Evolut transcatheter aortic valve replacement (TAVR) system was associated with similar clinical outcomes to its competitor Sapien, but also led to significant improvements in bioprosthetic valve dysfunction and quality of life in women. (MassDevice)

Patients on existing dual antiplatelet therapy were at higher risk of symptomatic intracerebral hemorrhage (ICH) from subsequent stroke thrombolysis, registry data showed. (JAMA Neurology)

No apparent harms were observed from resuming anticoagulant therapy within a week after ICH for patients with mechanical valves. (Journal of the American Heart Association)

Normobaric hyperoxia for 4 to 6 hours showed promise for controlling stroke severity among patients with acute ischemic stroke undergoing endovascular treatment. (Stroke)

A phase III trial on intravenous tenecteplase in the setting of minor ischemic strokes with intracranial occlusion was stopped early for futility and possible harm. (The Lancet)

Researchers developed a smartphone app that can automatically extract ECG waveforms from photos, enabling downstream machine learning-based diagnostics. (Heart)

Elixir Medical announced that 2 years into the BIOADAPTOR trial, the DynamX coronary bioadaptor device demonstrated a reduction in target lesion failure compared with a conventional drug-eluting stent.

Exercising frequently after age 40 did not stop the progression of coronary artery calcium (CAC), a cohort study found. (JAMA Cardiology)

Patients with stable coronary artery disease without standard modifiable cardiovascular risk factors have a substantial but significantly lower 5-year rate of subsequent cardiovascular death or non-fatal heart attack compared with those with risk factors. (European Heart Journal)

Like adults, children with out-of-hospital cardiac arrest may not benefit from active transport during CPR as opposed to continued on-scene CPR. (JAMA Network Open)

A Massachusetts hospital will pay $24.3 million to resolve healthcare fraud allegations related to insufficient evaluation of patients before TAVR, the Department of Justice said.

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