Preliminary data showed that viltolarsen (Viltepso), an exon-skipping drug that won accelerated approval to treat Duchenne muscular dystrophy in 2020, failed a 48-week phase III confirmatory trial, NS Pharma said.
NG2 glia may protect against prion neurotoxicity by inhibiting prostaglandin E2 signaling from microglia to neurons, lab and animal studies suggested. (Nature Neuroscience)
An artificial-intelligence system coupled with a brain implant decoded activity from a bilingual patient with paralysis into either Spanish or English words. (Nature Biomedical Engineering)
A resting-state functional MRI study in China demonstrated changes in brain function in COVID survivors versus healthy controls. (Lancet Regional Health-Western Pacific)
Multiple sclerosis differential diagnosis improved with combination of the central vein sign, paramagnetic rim lesions, and cortical lesions. (Neurology: Neuroimmunology and Neuroinflammation)
A set of papers from the PsychENCODE consortium mapped gene regulation networks in autism, schizophrenia, bipolar disorder, and other conditions. (Science)
Otsuka Pharmaceutical stopped developing AVP-786, a potential treatment for agitation associated with Alzheimer’s dementia, after a phase III trial missed its primary endpoint.
Urolithin A improved Alzheimer’s cognition in mice and restored mitophagy and lysosomal functions. (Alzheimer’s & Dementia)
And targeting plexin-B1 protein in an Alzheimer’s mouse model altered glial activation and amyloid compaction. (Nature Neuroscience)
Progression on the Clinical Dementia Rating scale and cognitive functioning measures predicted when older adults would stop driving. (Neurology)
A network meta-analysis supported multimodal interventions for slowing disease progression in amyotrophic lateral sclerosis, with an emphasis on exercise. (Scientific Reports)
Patients who attended a first-seizure clinic in Australia had fewer emergency department visits and hospital admissions, a retrospective study showed. (JAMA Neurology)
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