GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
(Pembrolizumab + quavonlimab) overview
Fixed dose combination of pembrolizumab and quavonlimab (MK-1308A) is under development for the treatment of advanced hepatocellular carcinoma, metastatic renal cell carcinoma, metastatic melanoma, metastatic colorectal cancer, small-cell lung cancer, non-small cell lung cancer and advanced clear cell renal cell carcinoma (ccRCC). It is administered by intravenous route as a solution. Quavonlimab acts by targeting cytotoxic T lymphocyte protein 4(CTLA4) and pembrolizumab acts by targeting programmed cell death protein 1.
Merck overview
Merck is a biopharmaceutical company with focus on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for the treatment of cardiovascular conditions, cancer, immune disorders, infectious and respiratory diseases, and diabetes, among others. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors, and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is headquartered in Rahway, New Jersey, the US.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.