Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.
Sarepta touts Duchenne gene therapy uptake, but warns of demand flattening before potential expanded label from FDA
Sarepta Therapeutics announced Wednesday afternoon that its Duchenne muscular dystrophy gene therapy Elevidys pulled in $200 million in its first half-year on the commercial market.
March 1, 2024