Common Drugs, Vaccines Tied to Less Dementia Risk; New LATE Criteria; Rethinking ALS

Antimicrobials, vaccinations, and anti-inflammatory drugs were associated with a reduced risk of dementia in a systematic review, while diabetes drugs, vitamins and supplements, and antipsychotics were tied to an increased risk. (Alzheimer’s and Dementia: Translational Research & Clinical Interventions)

A nanoparticle-based wireless deep brain stimulation system restored degenerated dopamine neurons in Parkinson’s disease. (Science Advances)

Researchers published initial clinical criteria for diagnosing limbic-predominant age-related TDP-43 encephalopathy (LATE), including LATE neuropathologic change. (Alzheimer’s and Dementia)

The thrombolytic prourokinase was not superior to standard care in people with mild ischemic stroke, the PUMICE trial in China showed. (JAMA Neurology)

Gray matter volume in women followed a U-shaped trajectory which dipped in late pregnancy and partially recovered during postpartum, longitudinal data showed. (Nature Communications)

A potentially novel meningoencephalomyelitis syndrome associated with vimentin autoantibodies emerged in a retrospective case series. (JAMA Neurology)

Modified human stem cells restored cortical excitability after ischemic stroke in rats. (Molecular Therapy)

Brains of young adults with sickle cell anemia appeared older. (JAMA Network Open)

The NIH will lead the National Plan to End Parkinson’s Act.

Here’s how amyotrophic lateral sclerosis (ALS) care and research can be reimagined. (JAMA Neurology)

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

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