Varipulse Returns; HCM Genes Reconsidered; Early Blood Test for Preeclampsia?

Johnson & Johnson said the U.S. rollout of the Varipulse pulsed field ablation platform is back on after an investigation found the devices operate as intended.

Can artificial intelligence (AI) identify underlying atrial fibrillation just from brain MRI scans? (eClinicalMedicine)

A Swedish cross-sectional study showed a U-shaped association between sodium intake and frequency of premature ventricular complexes. (Heart)

To predict arrhythmic risk in carriers of filamin C truncating variants, a novel risk predictive model was developed based on age, sex, syncope, nonsustained ventricular tachycardia, and left ventricular ejection fraction. (JAMA Cardiology)

Dozens of genes associated with hypertrophic cardiomyopathy (HCM) were reappraised based on their clinical validity. (Journal of the American College of Cardiology)

First-degree relatives of people with known premature cardiovascular disease may be reluctant to undergo a routine cardiovascular check-up themselves, according to a prospective study. (European Journal of Preventive Cardiology)

A test of cell-free DNA shed from the placenta during pregnancy showed promise for early prediction of preeclampsia. (Nature Medicine)

FDA 510(k) clearance was given to Roche’s Elecsys sFlt-1/PlGF ratio for stratifying hospitalized pregnant women with hypertensive disorders of pregnancy into low- and high-risk categories for severe preeclampsia, the company announced.

Trials in atherosclerotic cardiovascular disease were characterized as having heterogeneous endpoints that are often changed between trial design and publication. (JAMA Internal Medicine)

AI-based screening was more efficient in finding eligible patients for a heart failure clinical trial within the Mass General Brigham Health System. (JAMA)

WhiteSwell announced positive data supporting the use of its eLym System, in conjunction with diuretic therapy, for acute decompensated heart failure (ADHF).

Reprieve Cardiovascular reported that its physiological monitoring-based Reprieve System helped people with ADHF achieve decongestion while preserving kidney function in the FASTR pilot trial.

A phase II trial marks a setback for mitiperstat, a novel myeloperoxidase inhibitor, as it failed to improve NT-proBNP levels or left ventricular remodeling at 12 weeks in people with heart failure with reduced ejection fraction. (Circulation)

FDA alerted that Abiomed updated the use instructions for the recalled Impella RP with SmartAssist and Impella RP Flex with SmartAssist addressing the risk that the tip of guidewires or other medical devices may come into contact with the Impella pump during insertion, adjustment, or removal.

To what extent prosthesis-patient mismatch can be associated with outcomes after surgical aortic valve replacement seemed to differ by sex, a retrospective analysis found. (European Heart Journal)

From CT chest scans obtained for lung cancer staging or screening, concurrent coronary calcium scoring may also be performed, according to findings disseminated by the American College of Cardiology.

For heart attack patients who had undergone drug-eluting stenting, de-escalating dual antiplatelet therapy to ticagrelor (Brilinta) monotherapy cut bleeding risks in a meta-analysis of three randomized trials. (Annals of Internal Medicine)

The supposed neuroprotective agent nerinetide came up short in two more trials: it had no effect on functional outcomes for stroke patients getting endovascular therapy without an accompanying IV thrombolytic in one, and separately, when given before hospital arrival within 3 hours of symptom onset of suspected stroke. (The Lancet)

The Biophysical Society highlighted research showing that sweet taste receptors on the heart can modulate the heartbeat, perhaps explaining the link between artificially sweetened beverages and irregular heartbeats.

Lungs from donation after circulatory death were better used with concomitant heart procurement in the picture, regardless of procurement technique, according to an observational study. (JAMA Network Open)

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