New APA President-Elect; Novel Depression Drug Flops; Probiotics and Schizophrenia

The American Psychiatric Association (APA) named Mark Rapaport, MD, of the University of Utah, as the medical society’s next president-elect, with his tenure kicking off at the end of the annual meeting in May.

A Swedish cohort study found that kids with avoidant restrictive food intake disorder had significantly increased risks of being diagnosed with neurodevelopmental, gastrointestinal, endocrine or metabolic, respiratory, neurological, and allergic conditions. (JAMA Pediatrics)

Investigational drug SPN-820, which activates the mTORC1 pathway, failed to significantly reduce depressive symptoms compared with placebo in a phase IIb study of adults with treatment-resistant depression, said developer Supernus Pharmaceuticals.

From 2017 to 2022 in California, the share of buprenorphine prescribers working in the emergency department (ED) increased from 2% to 16%; and nearly one in three patients receiving buprenorphine for opioid use disorder in the ED received a second prescription within 40 days. (JAMA)

After 2017, sportsbooks expanded from a single U.S. state to 38 states, wagers increased from $4.9 billion to $121.1 billion in 2023, and online searches for gambling addiction rose by 23%. (JAMA Internal Medicine)

Despite continuous dopamine D₂ receptor blockade with long-acting injectable antipsychotics, the 10-year cumulative probability of relapse was 45% among patients with first-episode schizophrenia. (American Journal of Psychiatry)

A single intraoperative esketamine infusion significantly reduced the incidence of postpartum depression at 6 weeks postpartum, a randomized trial of pregnant women with cesarean delivery in China found. (JAMA Network Open)

A meta-analysis of five studies found a significant improvement in schizophrenia symptoms with probiotic supplementation. (Journal of Psychiatric Research)

A Mendelian randomization study suggested a causal link between narcolepsy and schizophrenia. (Translational Psychiatry)

Greater physical activity and less screen time were inversely tied with perceived stress and depressive symptoms in Finnish adolescents. (JAMA Network Open)

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