Adderall Alternatives; Alcohol Use Disorder Nasal Spray? Matthew Perry Fellowship

A study suggested that a shortage of immediate-release mixed amphetamine salts (Adderall) to treat attention deficit-hyperactivity disorder (ADHD) may have prompted a switch to alternative stimulants for kids. (Pediatrics)

From 2013 to 2024, the FDA approved 16 novel drugs to treat psychiatric diseases — three of which had more negative or failed efficacy trials than positive ones, including one antidepressant that was approved based on two positive trials but had 10 other failed trials, a cross-sectional study showed. (JAMA Network Open)

Combined with relapse prevention therapy, an intranasal formulation of 5-MeO-DMT benzoate reduced the average number of alcohol units consumed per day, from 9.3 to 2.2 units by week 12, in a phase IIa study, said developer atai Life Sciences.

The FDA approved a monthly maintenance dose of intravenous lecanemab (Leqembi) for early Alzheimer’s disease, drugmakers Eisai and Biogen announced.

Pregnant people exposed to acute heatwave periods in North Carolina had a 13% higher risk of severe mental illness, while prolonged exposure to moderate-intensity heatwaves was tied to a 37% higher risk, according to a matched analysis. (The Lancet Regional Health Americas)

A Department of Labor investigation on insurance coverage of mental health care revealed broad noncompliance and an “alarming” rate of ghost networks. (ProPublica)

Massachusetts General Hospital in Boston announced the creation of the Matthew Perry Foundation Fellowship in Addiction Medicine.

Since 2001, there has been a threefold to fivefold increase in the prevalence of sedative, hypnotic, or anxiolytic use disorders among adolescent and young adult Medicaid enrollees, a cross-sectional study showed. (Addiction)

Men and women with ADHD died 6.8 years and 8.6 years earlier than the general population, a matched cohort study from the U.K. suggested. (British Journal of Psychiatry)

Researchers found that heavy lifetime cannabis use was associated with lower brain activation during working memory tasks. (JAMA Network Open)

Depressive symptoms increased more among high school students engaging in no more than one health-risk behavior compared with those engaging in four to five health-risk behaviors. (The Lancet Regional Health Americas)

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