Ataciguat’s Headway in Aortic Stenosis; Baby Pacemakers; AI-ECG Tool for the ED?

The nitric oxide-independent soluble guanylate cyclase activator ataciguat continued to show promise for slowing the progression of fibrocalcific aortic valve stenosis in phase I and II studies. (Circulation)

The extent of myocardial fibrosis in aortic stenosis appeared to be a significant prognosticator for both men and women undergoing valve replacement in a prospective study. (JAMA Cardiology)

A single-center study suggested that a platelet-albumin-bilirubin score may be predictive of mortality after transcatheter aortic valve replacement. (Clinical Cardiology)

The FDA said that the recall of certain Boston Scientific pacemakers due to possible erroneous triggering of safety mode has been elevated to class I, the most serious type of recall.

A novel small pacemaker can be safely implanted in neonates and infants, according to a multicenter study. (Circulation: Arrhythmia and Electrophysiology)

In a move away from blanket restrictions for athletes with cardiovascular abnormalities, shared decision making for sports participation eligibility was emphasized in a scientific statement released by the American Heart Association and the American College of Cardiology.

Researchers identified 10 gene pairs that may contribute to congenital heart disease. (American Journal of Human Genetics)

An artificial intelligence (AI)-enhanced ECG model was able to detect acute myocardial infarction and predict 30-day major adverse cardiovascular events in a prospective validation study in Korean emergency departments (EDs). (European Heart Journal)

For left atrial appendage occlusion, the LAMax device may offer better prevention of device-related thrombus formation, and was similar in effectiveness as the standard Watchman 2.5, a randomized trial showed. (JACC: Asia)

Cryptogenic strokes in adults under 50 were tied to smoking in a European case-control study. (Neurology Open Access)

An older person’s frailty trajectory typically takes a turn for the worse following incident cardiovascular disease, according to a large longitudinal study. (European Journal of Preventive Cardiology)

In a randomized trial of patients with in-stent restenosis, a novel sirolimus-coated balloon was noninferior to a paclitaxel-coated balloon. (JACC: Cardiovascular Interventions)

A meta-analysis supported the link between non-malignant gynecologic diseases and cardiovascular or cerebrovascular diseases. (Heart)

Compared with men, women with abdominal aortic aneurysm were typically diagnosed almost a decade later and underwent repair less often, according to a population-based cohort study. (Mayo Clinic Proceedings)

A teenage boy was the first recipient of a totally robotic heart transplant, with a short ischemic time and mechanical ventilation under 24 hours. (Journal of Heart and Lung Transplantation)

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