According to GlobalData’s company profile on Bicycle Therapeutics, Nanoparticle drug conjugates was a key innovation area identified from patents. Bicycle Therapeutics‘s grant share as of February 2024 was 16%. Grant share is based on the ratio of number of grants to total number of patents.
High affinity binders of nectin-4 for treating diseases
The granted patent (Publication Number: US11912792B2) discloses a method for synthesizing compound BCY8245. The method involves a series of steps starting from providing compounds with specific formulas, such as formula 7, 6, 5, 4, 3, 2, and 1, and further reacting these compounds in a specific sequence to ultimately form the desired compound BCY8245 or its salt using solid-phase synthesis.
Additionally, the method includes specific reaction conditions and reagents for each step, such as reacting compound formula 8 with BCY8234 in the presence of N,N-diisopropylethylamine (DIEA), or reacting compound formula 7 with NHS in the presence of a carbodiimide like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI). The method also involves saponifying compound formula 6 with LiOH and H2O, reacting compound formula 5 with MMAE, and compound formula 4 with bis(4-nitrophenyl) carbonate, among other specific reactions. The hydrolyzing step is performed under acidic conditions to complete the synthesis process. Overall, the patent provides a detailed and specific method for synthesizing compound BCY8245, outlining the necessary compounds, reactions, and conditions required for the successful synthesis of the target compound.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies