Prime Medicine and Cimeio Therapeutics are partnering to develop gene-edited stem cell treatments for two kinds of bone marrow cancers and other potential genetic diseases, such as Gaucher syndrome and Hurler syndrome.
Financial terms were not disclosed. As part of the deal, Prime will be developing a gene editor for CD117, an antigen found on many kinds of cells, both healthy and cancerous. With the gene editor, Cimeio hopes to create stem cell transplants which can be paired with immunotherapies. Currently, patients have to receive very intense conditioning with chemoradiation to kill off the cells in their bone marrow before they can get a stem cell transplant.
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