‘Critically Impactful’ Drug Shortages; Emotions and Cancer; CRC Clues in Microbiome

In a recent survey, almost a third of healthcare system pharmacists said drug shortages are “critically impacting” patient care. (CNN)

Six months of aerobic exercise helped reduce chemotherapy-induced peripheral neuropathy among survivors of ovarian cancer. (Yale Cancer Center, JAMA Network Open)

A genetics analysis program driven by artificial intelligence showed good accuracy for classifying the primary source for cancer of unknown origin and predicting response to treatment. (Dana-Farber Cancer Institute, Nature Medicine)

Arcus Biosciences and Gilead Sciences have discontinued development of the A2 receptor antagonist etrumadenant for castration-resistant prostate cancer after disappointing results from an early-stage clinical study. (Pharmaphorum)

Contrary to long-standing clinical opinion, anxiety and depression do not contribute to worse outcomes in cancer. (Cancer)

Altered electrical signaling between two types of skin cells triggered the onset of melanoma in preclinical models. (American Association for Cancer Research)

The tumor microbiome of younger patients with rectal cancer differed from tissue samples obtained from older patients, pointing to a potential explanation for the rising incidence of colorectal cancer in people younger than 50. (University of Texas MD Anderson Cancer Center, Annals of Surgery)

The FDA converted an accelerated approval to full approval for pralsetinib (Gavreto) for metastatic RET fusion-positive non-small cell lung cancer.

Accuray announced FDA clearance of VitalHold to facilitate deep inspiration breath hold treatments with the company’s Radixact radiation therapy system.

Galera Therapeutics acknowledged receiving a complete response letter from the FDA, stating that an additional clinical trial will be required to establish the safety and efficacy of avasopasem for radiotherapy-induced severe oral mucositis.

CAR T-cell therapy demonstrated activity in preclinical models of recurrent, advanced ovarian cancer, leading to a first-in-human clinical trial. (City of Hope)

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