Dementia and Estrogen; Case Report on Fatality After Lecanemab; MRI-Based Brain Age

A nested case-control study showed that estrogen-only use in women was associated with a higher dementia rate compared with no estrogen use. (JAMA)

Folate or folic acid supplementation was tied to a higher risk of Alzheimer’s disease and changes in brain structure, but the effects were counteracted when other B vitamins were added. (The Journals of Gerontology: Series A)

Nature Communications reported the case of fatal iatrogenic cerebral beta-amyloid-related inflammation in a 79-year-old woman treated with lecanemab (Leqembi) for early Alzheimer’s in the open-label extension of the CLARITY-AD trial.

Repeated blows to the head in sports or combat were identified as a potential new risk factor for Parkinson’s disease. (npj Parkinson’s disease)

MRI-based brain age may help predict which patients with amyloid-negative amnestic mild cognitive impairment will convert to dementia. (Scientific Reports)

CDC data showed a gradual increase in mortality related to traumatic brain injury over the past decade, with the greatest increase in people age 75 and older. (JAMA Neurology)

The Pittsburgh Post-Gazette revisited the idea of Alzheimer’s disease as “type 3 diabetes.”

Artificial intelligence effectively screened for autism spectrum disorder using retinal photographs. (JAMA Network Open)

An augmented reality app distinguished healthy controls from otherwise healthy people who had Alzheimer’s pathology. (npj Digital Medicine)

A woman chronicled her 1,374 days with brain fog and other long COVID symptoms. (New York Times)

Are we ready for the insurance consequences of direct-to-consumer Alzheimer’s biomarker testing? (JAMA Neurology)

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

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