Diabetes Drugs Overpriced; Hormone Drugs and Brain Tumors; Menopause or Herpes?

Insulins, SGLT2 inhibitors, and GLP-1 receptor agonists can likely be manufactured for prices “far below” their current prices, according to an economic evaluation of manufacturing costs in JAMA Network Open.

In related news, Costco will offer a new weight loss program for its customers to include semaglutide (Ozempic). (USA Today)

Prolonged use of progestogen hormone drugs — widely used for endometriosis and polycystic ovary syndrome (PCOS) — was associated with an increased risk of intracranial meningioma brain tumors in a French population-based study. (BMJ)

Here’s why PCOS still lacks a specific FDA-approved treatment after nearly a century. (NBC News)

The novel GLP-1/glucagon dual receptor agonist pemvidutide yielded a mean weight loss of 15.6% at week 48 with 74.5% of weight loss from adipose tissue, according to more data from the phase II MOMENTUM trial. Developer Altimmune said that was comparable to compositional changes from diet and exercise.

There was statistically significant prolongation of the mean QTc interval by 19.1 ms over 6 months in a trial of transgender women and nonbinary or transfeminine individuals starting feminizing hormone therapy. (JAMA Network Open)

Actress Halle Berry said her menopause was initially misdiagnosed as herpes. (Los Angeles Times)

Greater exposure to the flame retardant polybrominated diphenyl ether (PBDE) — a type of endocrine-disrupting chemical — was linked with an increased risk of death from cancer over 17-year follow-up of more than 16,000 U.S. adults. (JAMA Network Open)

More Americans are adopting person-first language when discussing weight. (Axios)

The trail of people allegedly killed with insulin by an “erratic, disturbing, and abusive” nurse reached another Pittsburgh-area care home. (CBS News)

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