Antibody response to anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) may be a risk factor for multiple sclerosis (MS), a small study suggested. (JAMA Neurology)
ND0612, a subcutaneous levodopa-carbidopa infusion for Parkinson’s disease, increased on time without troublesome dyskinesia and reduced off time when used in combination with oral immediate-release levodopa-carbidopa in a phase III trial. (Lancet Neurology)
A forensic autopsy study showed that Lewy-related pathology started in middle age. (Annals of Neurology)
Researchers showed how the brain coordinates vocalization and respiration in mice. (Science)
Risks of cerebral hemorrhage with anti-amyloid drugs like lecanemab (Leqembi) suggest a need to create multidisciplinary treatment teams for Alzheimer’s disease, physicians argued. (JAMA)
From March 2020 through June 2021, people with epilepsy had a higher risk of being hospitalized with and dying from COVID-19 than controls, a study in Wales reported. (Epilepsia)
MRI features distinguished two common forms of autoimmune encephalitis from viral encephalitis and Creutzfeldt-Jakob disease. (JAMA Neurology)
The PrecivityAD2 Alzheimer’s blood test that combined an amyloid-beta 42/40 ratio and the percent of phosphorylated tau 217 showed an area under the curve of 0.94, yielding 88% agreement with amyloid PET. (Alzheimer’s and Dementia)
Risk of cavum septum pellucidum in older adults was driven more by the number of years in which repetitive head impacts were experienced in contact sports — especially American football — than the number of traumatic brain injuries. (Neurology)
A Virginia Commonwealth University-led registry of dementia cases and other neurodegenerative diseases is poised to become state law. (Virginia Mercury)
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