Fast-Acting Spray for PSVT; Undiscounted Entresto’s Value; CTCA-Aided Angiography

Genome-wide association studies suggested some genetic overlap between schizophrenia and cardiovascular disease risk factors, particularly BMI and smoking. (American Journal of Psychiatry)

People self-administering etripamil nasal spray during paroxysmal supraventricular tachycardia (PSVT) had a 60.2% probability of conversion within 30 minutes. (Journal of the American Heart Association)

Since U.S. guidelines lowered the cutoff for hypertension to 130/80 mm Hg, more patients with atrial fibrillation are meeting the CHA₂DS₂-VASc threshold for oral anticoagulation earlier in their disease course. (JAMA Network Open)

Heart transplantation outcomes at 1 year were comparable between circulatory death and brain death donations at a single center. (Journal of the American College of Cardiology)

There was no evidence that calcium channel blockers hurt heart failure outcomes in patients with mildly reduced or preserved ejection fraction across major trials. (European Journal of Heart Failure)

At the undiscounted wholesale price, sacubitril/valsartan (Entresto) was cost-effective relative to renin-angiotensin system inhibitors when treating heart failure with lower ejection fraction. (JAMA Cardiology)

Anumana announced that their ECG-AI LEF, an artificial intelligence (AI)-powered algorithm for detecting low ejection fraction based on routine 12-lead ECGs, received FDA clearance.

Also cleared is Qure.ai’s qXR-CTR AI algorithm for automating cardiothoracic ratio assessment from chest X-rays, the company reported.

Boston Scientific’s LUX-Dx II+ insertable cardiac monitor for long-term monitoring of arrhythmias also recently won FDA clearance. (Mass Device)

In addition, the FDA cleared the AVVIGO+ Multi-Modality Guidance System utilizing intravascular ultrasound and fractional flow reserve for percutaneous coronary interventions, Boston Scientific announced.

For patients with previous coronary artery bypass grafting, CT cardiac angiography (CTCA) reduced procedure times and complications compared with invasive coronary angiography, a single-center randomized trial showed. (Circulation)

Canadians with cannabis use disorder tended to have more adverse cardiovascular disease outcomes. (Addiction)

The risk of major vascular events after transient ischemic attack and minor ischemic stroke depends on the underlying cause of the index event. (JAMA Neurology)

A meta-analysis showed that even short-term exposure to air pollution is associated with an increased risk of stroke. (Neurology)

The Vienna Prediction Model underestimated recurrent venous thromboembolic events in low-risk individuals, but performed better after recalibration. (European Heart Journal)

Maintaining a healthy lifestyle reduced mortality and new diagnoses of type 2 diabetes in people with established cardiovascular disease. (European Journal of Preventive Cardiology)

Aggrey Kiyingi, the Ugandan cardiologist acquitted of killing his wife in 2006, has died in Australia. (New Vision)

Scientists found that zebrafish heart cells start beating suddenly and all at once to form a synchronized heartbeat. (Nature)

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