HCM Drug Hopeful; Pre-Cardiac Cath Fasting in Doubt; Way to Visualize LAAO Issues?

Even in states with laws requiring athletic facilities to have an on-site automated external defibrillator (AED), the odds of bystander AED use for cardiac arrests remain low. (JAMA Internal Medicine)

A quadriceps strength test predicted heart failure after acute coronary syndrome. (European Journal of Preventive Cardiology)

Investigational aficamten improved exercise capacity and secondary endpoints for people with obstructive hypertrophic cardiomyopathy in the SEQUOIA-HCM trial, according to Cytokinetics.

Successful uptitration of guideline-directed medical therapy to higher doses generally boded well for people discharged from the hospital for acute heart failure. (JAMA Cardiology)

CVRx announced that FDA approved a labeling update for Barostim baroreflex activation therapy for heart failure to cite positive post-market phase effectiveness analyses and expand the indication statement.

Fasting before cardiac catheterization was no safer than eating a heart-healthy diet with low-acid food, a randomized study found. (American Journal of Critical Care)

Beyond 1 year after percutaneous coronary intervention, clopidogrel (Plavix) monotherapy was not associated with differences in cardiovascular or bleeding events compared with aspirin monotherapy in STOPDAPT-2. (Journal of the American College of Cardiology)

For transcatheter aortic valve replacement, a novel implantation method for Evolut devices appeared to cut down on conduction disturbances requiring permanent pacemaker implants. (Circulation: Cardiovascular Interventions)

Coronary optic coherence tomography showed promise for visualizing left atrial appendage occluder endothelialization that may cause device‐related thrombus. (Journal of the American Heart Association)

Reteplase, a newer, more affordable stroke thrombolytic, worked as well as alteplase in a Chinese trial. (Stroke)

Stroke survivors did not show better motor recovery after a regimen of non-invasive brain stimulation, namely anodal transcranial direct current therapy, over 10 days in the subacute phase, a small study found. (Lancet Regional Health-Europe)

In atrial fibrillation, among the various subgroups sharing a CHA₂DS₂-VASc score of 1, the incidence of arterial thromboembolism did not differ significantly. (Circulation)

European centers practice differing ways of treating pericardial tamponade, the most frequent severe complication in the electrophysiology lab, survey shows. (EP Europace)

Mendelian randomization study finds that genetic associations with hypertensive disorders of pregnancy have a causal relationship with cardiovascular risk. (Heart)

Case report suggests that sotatercept may carry a risk of serious and recurrent gastrointestinal bleeding in people being treated for pulmonary arterial hypertension. (Annals of Internal Medicine)

Could a blood pressure drug targeting the DKK1-LRP5/6-GPCR pathway help prevent diabetic injuries? (European Heart Journal)

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