Muscle-Sparing Weight-Loss Drugs? AID Algorithm for T2D; Steroids and Heart Attacks

Pharmaceutical companies are developing new weight-loss treatments that aim to shed the pounds while preserving muscle mass — a downside of current drugs. (Reuters via MSN)

In a phase Ib trial, once-daily treatment with an investigational pill (ASC30) yielded an average 6.3% reduction in body weight after 28 days, developer Ascletis Pharma said.

Some participants in next-generation obesity trials are reportedly losing too much weight. (STAT)

Tandem Diabetes Care announced that the FDA cleared the company’s next-generation automated insulin delivery (AID) algorithm, Control-IQ+, for adults with type 2 diabetes (T2D). The AID algorithm was previously cleared for use in type 1 diabetes.

Chlorhexidine wipes didn’t significantly decrease the risk of new diabetic foot ulcers compared with soap-and-water wipes in a randomized trial. (JAMA Network Open)

HHS released new anti-transgender “sex-based definitions” guidance, which only recognizes two sexes.

A trial showed the iLet Bionic Pancreas system could be successfully initiated by both primary care providers and via telehealth in patients with type 1 diabetes, which could help expand access. (Clinical Diabetes)

The FDA delayed the final decision on the definition of “healthy” for food labels. (Reuters via MSN)

Eli Lilly said it launched two new strengths of tirzepatide (Zepbound) single-dose vials — 7.5 mg and 10 mg — for self-pay patients, and lowered the price of 2.5 mg and 5 mg vials.

A telehealth service offering cheaper GLP-1 agonists was supplied by a pharmacy lacking the required licensing to distribute compounded obesity drugs. (NPR)

In related news, over three dozen state attorneys general penned a letter to the FDA urging it to take action against companies selling counterfeit obesity drugs. (STAT)

With over 10 years of follow-up, the randomized SM-BOSS trial showed that Roux-en-Y gastric bypass was superior to laparoscopic sleeve gastrectomy when it came to lowering excess body mass index. (JAMA Surgery)

Risk for myocardial infarction was three times higher in anabolic androgenic steroid users over 11 years, a Danish study found. (Circulation)

Researchers in Endocrine Reviews described a few key hormones involved in skin aging.

Kristen Monaco is a senior staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.

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