A Columbia University-led multicenter research effort called IndiPHARM: individual metabolome and exposome assessment for pharmaceutical optimization will develop a platform and monitoring system to prevent unwanted interactions between medications and other environmental, genetic, and lifestyle factors, in order to optimize therapeutic efficacy.
Most disease-causing mutations that swap amino acids do so by making proteins less stable
Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.