Obesity Contributes to Top Killer; 22% Weight Loss With Novel Agent; PCOS Challenges

The American Heart Association reported that heart disease remains the leading cause of death, fueled by increases in risk factors like obesity and high blood pressure. (Circulation)

Risks for several kidney outcomes among patients with type 2 diabetes — including acute kidney injury, incident chronic kidney disease, or chronic kidney disease progression — were comparable over 6 years for those taking empagliflozin (Jardiance) versus dapagliflozin (Farxiga) in a Danish target trial emulation. (JAMA Internal Medicine)

In a large cohort study of commercially insured people with obesity, certain factors such as female sex and use of antidepressants were associated with initiation of semaglutide (Wegovy) in those without diabetes. (JAMA Network Open)

A study of postmenopausal women ages 50 and older showed an inverse association between intake of dietary niacin (vitamin B3) and osteoporosis. (Frontiers in Medicine)

Treatment with the highest dose of investigational injectable amycretin — a unimolecular GLP-1 and amylin receptor agonist — yielded a 22% weight loss after 36 weeks in a phase Ib/IIa trial, said developer Novo Nordisk.

Inpatient, outpatient, and medication expenditures similarly dropped by about 30% for people who underwent Roux-en-Y gastric bypass or sleeve gastrectomy in a retrospective study, mostly driven by reductions in pharmacy expenditures. (Annals of Internal Medicine)

A legal fight over a Florida law banning gender-affirming care for minors continues with oral arguments before a federal appeals court. (AP)

Fasting plasma glucose level, body mass index (BMI), older age, and male sex were tied to diabetes development, with significant interaction between these variables, according to a retrospective cohort study. (JAMA Network Open)

The only person in the world with a gene-edited pig kidney is thriving 2 months after the transplant. (AP)

Settling a lawsuit with Minnesota, Novo Nordisk agreed to cap out-of-pocket costs for its insulin at $35 per month, and to provide free insulin to certain patients, for 5 years, the state’s attorney general announced.

Exposure to traffic-related air pollution was linked to depression in healthy reproductive-age women in the Ovarian Aging Study, a relationship that was partially mediated by menstrual cycle length. (Menopause)

Researchers said there are still a number of challenges and uncertainties to the diagnosis of polycystic ovary syndrome (PCOS). (Journal of Clinical Endocrinology & Metabolism)

The Department of Justice dropped its case against Dallas doctor Eithan Haim, MD, who had been charged with leaking transgender care data. (Texas Tribune)

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