RAPT Therapeutics Inc Patent: Inhibiting Hematopoietic Progenitor Kinase 1 with Pyrazole Pyrimidine Compounds

According to GlobalData’s company profile on RAPT Therapeutics, Peptide pharmacophores was a key innovation area identified from patents. RAPT Therapeutics‘s grant share as of April 2024 was 30%. Grant share is based on the ratio of number of grants to total number of patents.

A recently granted patent (Publication Number: US11918582B2) discloses a compound of formula (I) and its pharmaceutically acceptable salts for the treatment of diseases associated with hematopoietic progenitor kinase 1 (HPK1) activity. The compound, not including a specific chemical structure, is designed to target HPK1, a key player in various diseases, particularly cancer. The patent also covers a pharmaceutical composition containing the compound and a method for treating diseases like cancer by administering the compound or its salt to patients in need.

Furthermore, the patent outlines a method for treating cancer using the disclosed compound in combination with anti-cancer drugs, specifically immune checkpoint inhibitors targeting various proteins like CTLA-4, PD-1, PD-L1, and others. The method covers a wide range of cancers, including brain, skin, breast, prostate, and blood cancers, among others. Additionally, the patent extends the application of the compound to treat diseases beyond cancer, such as viral and bacterial infections, age-related immune decline, and infertility. The compound’s chemical structure is not explicitly provided in the claims, emphasizing its broad applicability in treating a diverse range of diseases beyond cancer.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies