The revenue for Suzetrigine is expected to reach an annual total of $946 mn by 2040 globally based off GlobalData’s Revenue Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Suzetrigine Overview
VX-548 is under development for the treatment of post-operative pain (acute pain), diabetic peripheral neuropathy and painful lumbosacral radiculopathy (PLSR). The drug candidates act by targeting sodium channel protein type 10 subunit alpha.
Vertex Pharmaceuticals Overview
Vertex Pharmaceuticals (Vertex) is a biotechnology company that discovers, develops and commercializes transformative drugs for the treatment of serious and life-threatening diseases. The company’s product portfolio includes Trikafta, Symdeko/Symkevi, Orkambi (ivacaftor/lumacaftor), and Kalydeco (ivacaftor) for treating cystic fibrosis. Through its research and development efforts, the company focuses on cystic fibrosis, sickle cell diseases, beta thalassemia, type-1 diabetes and pain. It uses state-of-the-art technology platforms to discover new disease targets, compounds, delivery mechanisms, and treatment modalities. Vertex has R&D centers and commercial offices in North America, South America, Europe, and Australia. The company offers its products in the US, Europe, Australia, and Canada. Vertex is headquartered in Boston, Massachusetts, the US.
The company reported revenues of (US Dollars) US$9,869.2 million for the fiscal year ended December 2023 (FY2023), an increase of 10.5% over FY2022. In FY2023, the company’s operating margin was 38.8%, compared to an operating margin of 48.2% in FY2022. In FY2023, the company recorded a net margin of 36.7%, compared to a net margin of 37.2% in FY2022. The company reported revenues of US$2,690.6 million for the first quarter ended March 2024, an increase of 6.9% over the previous quarter.
For a complete picture of Suzetrigine’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.