Schizophrenia and Cannabis; RFK Jr.’s Antidepressant Misinfo; Services Down With 988

Incident cases of schizophrenia associated with cannabis use disorder almost tripled during a period of substantial liberalization of cannabis policy, a Canadian cohort study found. (JAMA Network Open)

In people with treatment-resistant depression, investigational inhalable mebufotenin yielded a 15.5-point placebo-adjusted reduction in Montgomery-Åsberg Depression Rating Scale score at day 8, meeting the phase IIb trial’s primary endpoint, said developer GH Research.

Some people with eating disorders may be misusing weight-loss injectables bought online. (Futurism)

Adverse childhood experiences for firstborn children were linked to an increase in mental health problems among their siblings, a cohort study in England suggested. (Lancet Public Health)

Experts explain why Robert F. Kennedy Jr.’s misinformation on antidepressants is problematic. (USA Today)

About 26% of grant abstracts funded by the National Institute on Drug Abuse used a stigmatizing term related to substance use in 2023 — a substantial drop from 54% of abstracts in 2013. (JAMA Network Open)

AbbVie said it will move forward with its investigational oral antipsychotic emraclidine as an adjunct treatment for schizophrenia after it failed as monotherapy in two phase II trials last year.

The launch of the 988 suicide and crisis lifeline did not appear to result in any substantial growth in the availability of most crisis services, with the exception of a small increase in peer support services. (JAMA Psychiatry)

Every $100 invested in an employer-sponsored behavioral health program with access to psychotherapy and medication management was tied to a $190 reduction in medical claims costs in a retrospective study. (JAMA Network Open)

A large review of studies concluded that antidepressants significantly reduced generalized anxiety disorder symptoms in the short term. (Cochrane Database of Systematic Reviews)

A Washington State bill wants to limit the number of patients with mental illness charged with crimes that each county can send to state psychiatric hospitals. (Seattle Times)

Researchers uncovered a potential link between contact traumas and endometriosis in a case-control study, independent of genetic predisposition to the condition. (JAMA Psychiatry)

Low-dose doxepin tablets approved for insomnia had much higher prices and fewer 30-day prescriptions compared with similar doses of capsules or liquid doxepin used off-label for insomnia, a study showed. (JAMA)

Researchers developed the 5-item Brief Eating Disorder Screener as the first screener validated for a broad range of DSM-5 eating disorder diagnoses. (General Hospital Psychiatry)

A global study of prisoners found a 12.8% prevalence of depression, while the prevalence of any psychosis was 4.1%. (Lancet Public Health)

Nearly all states had higher rates of drug-related deaths from 2020 to 2023 compared with 2019. (JAMA Network Open)

Please enable JavaScript to view the

comments powered by Disqus.