A special liquid diet, known as exclusive enteral nutrition, is an essential therapy for Crohn’s disease. Patients consume only this formula for six to eight weeks, completely avoiding solid foods. However, the exact reasons why this is helpful were previously unclear.
Nutrient metabolism regulates T cell exhaustion and therapy potential
Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.