T1D Trial Paused After Deaths; Mounjaro Not Just Cosmetic; Late-Stage Hot Flash Win

Vertex Pharmaceuticals put its phase I/II study of the investigational type 1 diabetes treatment VX-880 on a protocol-specified pause following two patient deaths that the company said were unrelated to the study drug.

Merck is looking to develop GLP-1 receptor agonist treatments that do more than just help with weight loss, the company’s CEO said. (Reuters)

Meanwhile, Eli Lilly warned that its popular GLP-1 agent tirzepatide (Mounjaro, Zepbound) shouldn’t be used just for “cosmetic” weight loss. (The Hill)

Tandem Diabetes announced that its t:slim X2 insulin pump with Control-IQ technology is the first automated insulin delivery system to integrate with Abbott’s FreeStyle Libre 2 Plus sensor.

Do people eat more calories after stopping weight loss drugs? A Deutsche Bank survey indicated so. (CNBC)

The FDA is investigating reports of alopecia, aspiration, and suicidal ideation in people taking GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide. However, a recent study actually showed a lower suicidal ideation risk with semaglutide compared with non-GLP-1 anti-obesity medications. (CNN)

Rising malpractice premiums are pricing small clinics out of gender-affirming care for minors. (KFF Health News)

Bayer said that two phase III trials testing the investigational, non-hormonal elinzanetant for moderate to severe vasomotor symptoms in postmenopausal women met all primary and key secondary endpoints.

Though overall cognition didn’t change, people with class II/III obesity who underwent bariatric surgery had a significant improvement in executive functioning. (Journal of Nutrition, Health & Aging)

Bias in healthcare may be behind misdiagnoses of latent autoimmune diabetes of adults, which can lead to mismanagement of the disease. (NBC News)

An investigation found that the endocrine-disrupting chemicals bisphenols and phthalates — plasticizers used to make plastic more flexible and durable — remain widespread in food. (Consumer Reports)

Exposure to more green space was linked with significantly higher bone mineral density in young kids. (JAMA Network Open)

Kristen Monaco is a senior staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.

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