UCSF scientists aim to unravel autism with brain organoids and AI

Re­searchers are be­gin­ning to un­rav­el how 100 genes pre­vi­ous­ly linked to autism spec­trum dis­or­der may im­pact brain de­vel­op­ment, an im­por­tant step to­ward bet­ter un­der­stand­ing the con­di­tion that could one day lead to new ther­a­pies.

A new study from sci­en­tists at the Uni­ver­si­ty of Cal­i­for­nia, San Fran­cis­co, com­bines pro­teomics ex­per­i­ments and AI-pow­ered sim­u­la­tions to iden­ti­fy more than 1,700 in­ter­ac­tions be­tween pro­teins im­pli­cat­ed in autism and how ge­net­ic mu­ta­tions found in peo­ple with autism im­pact those pro­tein-pro­tein in­ter­ac­tions.

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